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KMID : 0352720160400030245
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Journal of Ginseng Research
2016 Volume.40 No. 3 p.245 ~ p.250
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Complete 1H-NMR and 13C-NMR spectral assignment of five malonyl ginsenosides from the fresh flower buds of Panax ginseng
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Yu-Shuai Wang
Yin-Ping Jin
Wei Gao
Yu-Wei Zhang
Pei-He Zheng
Jia Wang
Jun-Xia Liu
Cheng-He Sun
Ying-Ping Wang
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Abstract
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Background: Ginsenosides are the major effective ingredients responsible for the pharmacological effects
of ginseng. Malonyl ginsenosides are natural ginsenosides that contain a malonyl group attached to a
glucose unit of the corresponding neutral ginsenosides.
Methods: Medium-pressure liquid chromatography and semipreparative high-performance liquid
chromatography were used to isolate purified compounds and their structures determined by extensive
one-dimensional- and two-dimensional nuclear magnetic resonance (NMR) experiments.
Results: A new saponin, namely malonyl-ginsenoside Re, was isolated from the fresh flower buds of
Panax ginseng, along with malonyl-ginsenosides Rb1, Rb2, Rc, Rd. Some assignments for previously
published 1
H- and 13C-NMR spectra were found to be inaccurate.
Conclusion: This study reports the complete NMR assignment of malonyl-ginsenoside Re, Rb1, Rb2, Rc,
and Rd for the first time.
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KEYWORD
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flower buds, ginsenoside, malonyl ginsenoside Re, NMR, Panax ginseng
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